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Salvianolic Acid C
Catalog No. T3149Cas No. 115841-09-3
Salvianolic Acid C is extracted from the root of Salvia miltiorrhiza, a perennial plant in the genus Salvia.
Salvianolic Acid C
Catalog No. T3149Cas No. 115841-09-3
Salvianolic Acid C is extracted from the root of Salvia miltiorrhiza, a perennial plant in the genus Salvia.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $36 | In Stock | |
| 5 mg | $80 | In Stock | |
| 10 mg | $122 | In Stock | |
| 25 mg | $255 | In Stock | |
| 50 mg | $378 | In Stock | |
| 100 mg | $558 | In Stock | |
| 500 mg | $1,190 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $87 | In Stock |
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Purity:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Salvianolic Acid C is extracted from the root of Salvia miltiorrhiza, a perennial plant in the genus Salvia. |
| Targets&IC50 | CYP2C8:4.82 μM (Ki), CYP2J2:5.75 μM (Ki) |
| In vitro | METHODS: Human periodontal stem cells hPDLSCs were pretreated with Salvianolic acid C (0-5 mM) for 1 h, then cultured with LPS (1 µg/mL) for 24 h. Cytokines were detected using ELISA kits. RESULTS: Salvianolic acid C treatment significantly inhibited the expression of TNFα, IL-6 and IL-1β in a dose-dependent manner. [1] METHODS: HEK293T cells stably expressing human-ACE2 were treated with Salvianolic acid C (0-100 µM), and viral entry was studied using the SARS-CoV-2 HSCs pseudovirus (PsV) system. RESULTS: Salvianolic acid C inhibited SARS-CoV-2 PsV entry on 293T/ACE2 cells with an IC50 of 3.85 µM.[2] |
| In vivo | METHODS: To investigate the effects on liver injury, Salvianolic acid C (5-20 mg/kg) was intraperitoneally injected into C57BL/6J mice with CCl4-induced hepatic fibrosis once a day for six days, followed by APAP (400 mg/kg) to induce liver injury. RESULTS: Salvianolic acid C protects hepatocytes from APAP-induced injury by attenuating mitochondrial oxidative stress, inflammatory response, and cystatinase-mediated anti-apoptotic effects via inhibition of the Keap1/Nrf2/HO-1 signaling axis. [3] |
| Molecular Weight | 492.43 |
| Formula | C26H20O10 |
| Cas No. | 115841-09-3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5.5 mg/mL (11.17 mM), Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.  DMSO: 55 mg/mL (111.69 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
10% DMSO+40% PEG300+5% Tween 80+45% Saline/DMSO
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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